Autoimmune type 1 diabetes is often diagnosed in Stage 3, when symptoms occur. Unfortunately, many people find out they have type 1 diabetes in a traumatic way: after a serious complication like diabetic ketoacidosis causes a trip to the emergency room. Thankfully, proactive screening for autoimmune type 1 diabetes could help reduce the risk of DKA and other complications.
The American Diabetes Association recommends proactively screening high-risk patients for autoimmune type 1 diabetes with a blood test that can detect it in the early stages.
If you know where you or your loved one is with T1D progression, you may be able to take action to get ahead of it. TZIELD could delay the onset of Stage 3,* which is when your body can’t make enough insulin on its own and may require insulin injections, and could give more time to prepare. But TZIELD should only be given in a certain—and limited—time frame.
*In appropriate people.
Screening is the first step in determining whether TZIELD may be an option for you.
Even though Mary has had type 1 diabetes for many years and is an advocate for the community, it was only recently that she heard of early detection and TZIELD. She’s passionate about getting the word out and hopes people can have an easier time transitioning to a T1D lifestyle than she did.
Unlike a blood sugar level test, an autoantibody blood screening looks for early signals of autoimmune type 1 diabetes and is used to determine the risk of developing it.
Screening is often low or even no cost depending on insurance, and knowing there are signs of autoimmune type 1 diabetes lets people act early and proactively seek out monitoring, management, or potential treatment with TZIELD if appropriate.
There are 3 possible screening results:
Zero type 1 diabetes autoantibodies found
What to do:
It can be helpful to talk to a doctor about getting rescreened every year, especially with a family history of autoimmune type 1 diabetes.
One type 1 diabetes autoantibody found
What to do:
This result means a person is more likely to develop autoimmune type 1 diabetes than someone with no autoantibodies present. Talk to a doctor about monitoring, making sure you have been screened for all 5 autoantibodies, and about a rescreening schedule and next steps.
Two or more type 1 diabetes autoantibodies found
What to do:
This result points to the early stages of autoimmune type 1 diabetes. Talk to a doctor about more testing and ask if TZIELD may be an option.
TALK TO A DOCTOR ABOUT A PLAN TO MANAGE AUTOIMMUNE TYPE 1 DIABETES
There are several ways to get screened for early-stage autoimmune type 1 diabetes:
SCREENING OPTIONS FOR TYPE 1 DIABETES
| TYPE 1 DIABETES–RELATED AUTOANTIBODIES | |||||||
|---|---|---|---|---|---|---|---|
| AMERICAN DIABETES ASSOCIATION RECOMMENDED | |||||||
| WHERE TO GET IT | TYPE OF TEST | COST | GADA | IA-2A | IAA | ZnT8A | ICA |
| Doctor’s office or lab* You can get screened at a doctor’s office, or at a lab like Labcorp® or Quest Diagnostics® | Blood draw | Most insurance plans cover some or all of the cost |  | | | | |
| Type 1 Diabetes Screening Central* All US residents can speak with a screening counselor, make a telehealth appointment, or get a screening order or home kit Screenfortype1.com | Blood draw or finger stick | Costs are variable based on services | | | | | Varies depending on |
| Autoimmunity Screening via ASK†All U.S. residents can order at-home screening kits online. Residents of Colorado can also get kits at certain screening locations AskHealth.org | Blood draw or finger stick | Free for U.S. residents aged 1 year and older with or without a family history of type 1 diabetes | | | | | |
| Online orderingScreening kits can be ordered by your provider online from vendors like Enable Biosciences | Finger stick | Most insurance plans cover some or all of the cost | | | | ||
| TrialNet‡,§Screening can take place at TrialNet locations, events, or health fairs. You can also receive a screening kit to use at home or to bring in to a Labcorp® or Quest Diagnostics® location TrialNet.org/participate | Blood draw or finger stick | Free for people with a first-degree relative with type 1 diabetes | |  | | | |
These are not all of the screening options available. It’s important to talk to your doctor about the best screening option for you. Inclusion on this list does not imply the endorsement of Sanofi.
*Selection of autoantibody assays are at the HCP’s sole discretion.
† Autoimmunity Screening for Kids.
‡ TrialNet will initially test for 2 autoantibodies. If 1 or more autoantibodies are found in the first test, additional testing may
be done for other autoantibodies as indicated by the grey check-marked boxes.
§ For ages 2.5–45 years old with a first-degree relative and 2.5–20 years old with a second-degree relative.
A type 1 diagnosis can be a traumatic and sudden experience accompanied by a serious health scare. Early screening could help!
Screening is often available at little or no cost.
Talk to your doctor about early screening and treatment options.
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.