TZIELD COMPASS SUPPORT PROGRAM

TZIELD indication card
John VO:
“I am being compensated by Sanofi to share my story.”

John, TZIELD Patient
[Compensated by Sanofi]
“Fortunately, I visited the TZIELD website and got connected with the COMPASS Navigator program. Within a day of me reaching out, I had a phone conversation with a Navigator, and she was so helpful. She was able to explain to me about the process, help me understand the paperwork needed, got connected with my endocrinologist clinic, and helped me understand the timelines of what things looked like next.”

“Getting connected with the COMPASS Navigator and talking through with someone who understood TZIELD and what I was going through was impactful to me. I felt like I was in a circumstance that I had never experienced before, so being able to have that advocate and who understood the experience and leaned into my experience and heard what I was saying was really important to me and made a difference in my experience with my healthcare journey.”

See John’s full story on the Real Talk About Type 1 & TZIELD page

[TZIELD logo]

What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects. These include:

• Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
• Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD?

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

• have a serious infection or an infection that does not go away or keeps coming back
• have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
• are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
• are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

• rash
• leukopenia (decrease in white blood cell counts)
• headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see [accompanying] Medication Guide and Prescribing Information.

MAT-US-2306423-v2.0-01/2024